Mesenchymal Stem Cell Rheumatoid Arthritis

They are expected to be a solution for numerous human conditions.

Mesenchymal stem cell rheumatoid arthritis.

The role of mesenchymal stem cells msc in experimental arthritis is undoubtedly conflicting. Rheumatoid arthritis ra is the commonest autoimmune joint disease that has witnessed significant t the vast majority of literature pertaining to mesenchymal stem cells msc immunomodulation has focussed on bone marrow derived msc that are systemically infused to alleviate inflammatory conditions. El jawhari 1 2 y m. However in rheumatoid arthritis ra and spondyloarthritis spa subsets of subchondral bm mscs might conversely fuel synovitis and enthesitis.

The purpose of this review is to highlight recent developments and current knowledge gaps in our understanding of the protective effects of mscs against inflammatory arthritis and to discuss their clinical exploitation. Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis. Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint arthritis rheum 2000 43. Ra is a systemic autoimmune disorder characterised by aberrant leukocyte infiltration persistent inflammation of synovium and proteases within the joint which ultimately leads to cartilage and bone destruction.

Mesenchymal stromal stem cells mscs have potent anti inflammatory and immunomodulatory properties in addition to their ability to form cartilage and bone. Inflammation is preceded by tumor necrosis factor dependent infiltration of mesenchymal cells in experimental arthritis. Wang l wang l cong x liu g zhou j bai b et al. The study is a single dose phase i clinical trial and is the first time that this product will be infused in ra patients.

Jones 1 and d. Mcgonagle 1 from the 1 leeds institute of rheumatic and musculoskeletal medicine st. James university hospital wtbb ls9 7tf university of leeds uk and 2 clinical pathology department faculty of medicine. 12 marinova mutafchieva l willimas ro funa k maini rn zwaifler nj.

This is a prospective multicenter double blind placebo controlled interventional study to evaluate the safety and efficacy of allogeneic mesenchymal stem cells mscs in 20 patients with new onset rheumatoid arthritis ra. El sherbiny 1 2 e a. Bone marrow mesenchymal stem cells bm mscs can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis.